In many clusters, there is now cryoEM data that identifies that 2 different genes are needed to make the capsid, one that forms the pentamers and another forming the hexamers. this has been best worked out in Rosebush, a Cluster B2 phage. The hexamer gene is part of pham (102634) that has members in 358 phages that include 4 singletons, and Clusters AD, AP, B, BG, DC, DE, DR, EC, EG, EI, GC, and W.

The pentamer gene is part of pham 20839, but there is sequence similarity to 2 other phams - 21303 and 102541.Work is being done to verify whether these proteins fold in a similar manner. We won't call them…yet. But cool.