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TerD, tellurium resistance protein

| posted 14 Jul, 2019 21:22
Hello,

We would like to propose the addition of TerD or tellurium resistance protein, or the equivalent, to the approved function list. We believe pham 15777, which currently includes:

  • Geostin gene 71 (39028 - 39609)
  • FlowerPower gene 76 (39028 - 39609)
  • Fabian_Draft gene 79 (39358 - 39939)

  • Shows compelling evidence for the functional call.

    Examination of the protein sequence here:

    >Geostin gp71
    MINLTKGSAPVTLSKAARMSVRITWPAATDYDAGAEILYKDGTTESIATFGARGVDAKLTSLTGKVRHNGDATRGAGTATETIDIDHDDEIVEIRPWAYSAQSNGTGSFRKYAVSMEVSNGTDTVKIDANNASNHDNVYTCVPAVLRFTGDGVQVEYAELYSDPRSEARPAFKKSGLLGKLKFTMDGPRNNYK

    By HHPred: https://toolkit.tuebingen.mpg.de/#/jobs/SEAGEOSTIN71

    And by BlastP: https://blast.ncbi.nlm.nih.gov/Blast.cgi?CMD=Get&RID=JPXJD11B01R

    Shows high coverage and high confidence matches to the tellurium resistance protein TerD in multiple bacterial species.

    A brief literature search found that the gene has been found in phages infecting :

    Salmonella and Cronobacter spp.: https://bmcgenomics.biomedcentral.com/articles/10.1186/1471-2164-14-481 and https://atrium.lib.uoguelph.ca/xmlui/handle/10214/7414,
    Pseudomona spp https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4178739/,
    Clostridium spp. https://www.ncbi.nlm.nih.gov/pubmed/17322187, and
    Bacillus spp.: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4178739/

    The domain, as shown in Phamerator is also found by the CDD: https://www.ncbi.nlm.nih.gov/Structure/cdd/wrpsb.cgi?RID=JPXJCJHM01R

    Thanks,

    Steve








    Edited 14 Jul, 2019 21:23
    | posted 15 Jul, 2019 14:53
    Hi Steve,
    We think "tellurium resistance protein D family" is the way to go. "Ter" is also the TLA for the terminase genes (which we also don't use) and we may sow confusion if we don't spell things out.

    Thanks!
    | posted 15 Jul, 2019 17:07
    Excellent, thanks!

    Steve
    | posted 29 Jul, 2019 16:44
    Hi Welkin,

    Just double-checking before submission. If we are naming the protein product, shouldn't it be "tellurium resistance D family protein", rather than "tellurium resistance protein D family"?

    Ivan
    | posted 03 Aug, 2019 21:15
    Welkin,

    Should we use D family protein or protein D family? I think that's all we need, then can submit.

    Thanks!

    Steve
     
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