SEA-PHAGES | TerD, tellurium resistance protein

Link to this post \| posted 14 Jul, 2019 21:22
scaruso	Hello, We would like to propose the addition of TerD or tellurium resistance protein, or the equivalent, to the approved function list. We believe pham 15777, which currently includes: Geostin gene 71 (39028 - 39609) FlowerPower gene 76 (39028 - 39609) Fabian_Draft gene 79 (39358 - 39939) Shows compelling evidence for the functional call. Examination of the protein sequence here: >Geostin gp71 MINLTKGSAPVTLSKAARMSVRITWPAATDYDAGAEILYKDGTTESIATFGARGVDAKLTSLTGKVRHNGDATRGAGTATETIDIDHDDEIVEIRPWAYSAQSNGTGSFRKYAVSMEVSNGTDTVKIDANNASNHDNVYTCVPAVLRFTGDGVQVEYAELYSDPRSEARPAFKKSGLLGKLKFTMDGPRNNYK By HHPred: https://toolkit.tuebingen.mpg.de/#/jobs/SEAGEOSTIN71 And by BlastP: https://blast.ncbi.nlm.nih.gov/Blast.cgi?CMD=Get&RID=JPXJD11B01R Shows high coverage and high confidence matches to the tellurium resistance protein TerD in multiple bacterial species. A brief literature search found that the gene has been found in phages infecting : Salmonella and Cronobacter spp.: https://bmcgenomics.biomedcentral.com/articles/10.1186/1471-2164-14-481 and https://atrium.lib.uoguelph.ca/xmlui/handle/10214/7414, Pseudomona spp https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4178739/, Clostridium spp. https://www.ncbi.nlm.nih.gov/pubmed/17322187, and Bacillus spp.: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4178739/ The domain, as shown in Phamerator is also found by the CDD: https://www.ncbi.nlm.nih.gov/Structure/cdd/wrpsb.cgi?RID=JPXJCJHM01R Thanks, Steve Edited 14 Jul, 2019 21:23

Link to this post | posted 14 Jul, 2019 21:22

Hello,

We would like to propose the addition of TerD or tellurium resistance protein, or the equivalent, to the approved function list. We believe pham 15777, which currently includes:

Geostin gene 71 (39028 - 39609)

FlowerPower gene 76 (39028 - 39609)

Fabian_Draft gene 79 (39358 - 39939)

Shows compelling evidence for the functional call.

Examination of the protein sequence here:

>Geostin gp71
MINLTKGSAPVTLSKAARMSVRITWPAATDYDAGAEILYKDGTTESIATFGARGVDAKLTSLTGKVRHNGDATRGAGTATETIDIDHDDEIVEIRPWAYSAQSNGTGSFRKYAVSMEVSNGTDTVKIDANNASNHDNVYTCVPAVLRFTGDGVQVEYAELYSDPRSEARPAFKKSGLLGKLKFTMDGPRNNYK

By HHPred: https://toolkit.tuebingen.mpg.de/#/jobs/SEAGEOSTIN71

And by BlastP: https://blast.ncbi.nlm.nih.gov/Blast.cgi?CMD=Get&RID=JPXJD11B01R

Shows high coverage and high confidence matches to the tellurium resistance protein TerD in multiple bacterial species.

A brief literature search found that the gene has been found in phages infecting :

Salmonella and Cronobacter spp.: https://bmcgenomics.biomedcentral.com/articles/10.1186/1471-2164-14-481 and https://atrium.lib.uoguelph.ca/xmlui/handle/10214/7414,
Pseudomona spp https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4178739/,
Clostridium spp. https://www.ncbi.nlm.nih.gov/pubmed/17322187, and
Bacillus spp.: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4178739/

The domain, as shown in Phamerator is also found by the CDD: https://www.ncbi.nlm.nih.gov/Structure/cdd/wrpsb.cgi?RID=JPXJCJHM01R

Thanks,

Steve

Edited 14 Jul, 2019 21:23

Link to this post \| posted 15 Jul, 2019 14:53
welkin	Hi Steve, We think "tellurium resistance protein D family" is the way to go. "Ter" is also the TLA for the terminase genes (which we also don't use) and we may sow confusion if we don't spell things out. Thanks!

Link to this post \| posted 15 Jul, 2019 17:07
scaruso	Excellent, thanks! Steve

Link to this post \| posted 29 Jul, 2019 16:44
ivanerill	Hi Welkin, Just double-checking before submission. If we are naming the protein product, shouldn't it be "tellurium resistance D family protein", rather than "tellurium resistance protein D family"? Ivan

Link to this post \| posted 03 Aug, 2019 21:15
scaruso	Welkin, Should we use D family protein or protein D family? I think that's all we need, then can submit. Thanks! Steve

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TerD, tellurium resistance protein