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DNA Primase

| posted 15 Sep, 2016 18:20
The DNA primase of the cluster A phages is split into two overlapping reading frames. The upstream portion of the gene is frequently missed by Glimmer and Genemark. We are not sure what happens within the cell during the infection to generate the correct full length primase, so for now, we add both parts to the annotations with a large overlap.
| posted 06 Mar, 2017 21:03
Thanks, Welkin. I was just encountering this in our A4 phage, and was wondering "what's up with that?!" I haven't looked closely yet for any slippery sequences, but it's not another frameshift that we're seeing? Neat!
| posted 03 Jun, 2019 17:42
Here is an example of where the overlapping primase gene should be added to a cluster A annotation. Power point slide by Chris Brey.
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