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Debbie Jacobs-Sera posted in Help with Annotating Direct Terminal Repeats
Marie Fogarty posted in Help with Annotating Direct Terminal Repeats
cdshaffer posted in Help with Annotating Direct Terminal Repeats
Marie Fogarty posted in Help with Annotating Direct Terminal Repeats
Debbie Jacobs-Sera posted in Potential minor tail proteins in cluster GK
antitoxin in toxin/antitoxin system, BrnA-like
| Link to this post | posted 20 May, 2021 19:41 | |
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This is a follow-up to the toxin BrnT posts https://seaphages.org/forums/topic/4458/. Like Paola (K5), SoSeph (K5) also has a pair of genes that looks like the BrnTA toxin/antitoxin pair of genes [SoSeph_draft_88 (57177-57455) and SoSeph_draft_89 (57457-57888 )]. As Jordan, Veronique and Kristen described in the BrnT discussion, the downstream antitoxin gene has a ribbon-helix-helix structure. In HHPred, it hits the KacA antitoxin crystal in and RelD and CopG antitoxin CCD domains, all of which are also members of type II toxin-antitoxin systems. We propose that this ribbon-helix-helix protein be called "antitoxin in toxin/antitoxin system, BrnA-like". It has the predicted ribbon-helix-helix motif of the antitoxin, the predicted size (ie, larger than the toxin), and the predicted synteny (immediately downstream of the toxin in a potential two-gene operon). BrnTA structure-function paper (Heaton et al., 2012) https://www.jbc.org/article/S0021-9258(20)53133-5/fulltext The official function list includes the BrnT toxin but does not include the partner BrnA antitoxin. |
| Link to this post | posted 20 May, 2021 19:52 | |
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It does now. Sorry about the  snafu! i am getting notices every time you try to fix it.
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