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Debbie Jacobs-Sera posted in Two endolysins?
adiaz posted in Two endolysins?
sklambet@ncsu.edu posted in Tail Assembly Chaperone- Translational Frameshift
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sklambet@ncsu.edu posted in Tail Assembly Chaperone- Translational Frameshift
hypothetical or NKF
| Link to this post | posted 11 Feb, 2025 16:10 | |
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We are annotating a large genome from FC cluster. What is the distinction between calling a gene product a protein with "unknown function" versus calling it "hypothetical protein"? |
| Link to this post | posted 11 Feb, 2025 17:38 | |
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Hi Olga, Technically there is no difference. However, "Hypothetical Protein" is the only acceptable choice. debbie |
| Link to this post | posted 11 Feb, 2025 17:41 | |
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How do you mean? If given an option, is calling it hypothetical protein more or less accurate? |
| Link to this post | posted 11 Feb, 2025 19:03 | |
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Olga, The answer is not about accuracy. Rather more about convention and acceptable practice. It is a historical decision between our program and NCBI. It was agreed that Hypothetical Protein was an acceptable term that both parties (SEA-PHAGES and NCBI) was willing to propagate without changing. So while unknown function could be used, it is not. the programs that categorize this stuff needs continuity to function properly, leading us to adopt Hypothetical Protein as a best choice. debbie |
| Link to this post | posted 12 Feb, 2025 16:10 | |
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Understood! |