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Recent Activity

capsid fusion

Link to this post \| posted 25 Apr, 2018 17:23
welkin	In the BI phages, the capsid maturation protease, scaffolding, and major capsid protein are fused together in a single gene.

Link to this post \| posted 25 Mar, 2019 16:45
scaruso	We used the function "major capsid and protease fusion protein," the current version of "capsid & capsid maturation protease" of the cluster AM phages (see Pham 17557). Should another function be created, perhaps that recognizes all three domains? Steve

Link to this post \| posted 25 Mar, 2019 16:59
welkin	Hi Steve, At this point we are not differentiating in our function names for other capsid-scaffolding fusions; as this is not uncommon in phages. In the case of HK97, the scaffolding is called the "delta domain" of the major capsid protein, and the literature refers to the procapsid or uncleaved form vs the mature form. So to be consistent, we have not labeled our capsids with delta domains anything other than "major capsid protein"–and so therefore, don't mention specifically it here either.

Link to this post | posted 25 Mar, 2019 16:59

welkin

Hi Steve,
At this point we are not differentiating in our function names for other capsid-scaffolding fusions; as this is not uncommon in phages. In the case of HK97, the scaffolding is called the "delta domain" of the major capsid protein, and the literature refers to the procapsid or uncleaved form vs the mature form. So to be consistent, we have not labeled our capsids with delta domains anything other than "major capsid protein"–and so therefore, don't mention specifically it here either.