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SAM lyase ?

| posted yesterday, 19:34
There are several putative SAM-degrading enzymes in HollowPurple (e.g., SAM lyase –gp#120 w/ stop codon at 62,755 – evidence is based on HHpred hits; see the entry in PECAAN). If real, these are probably a counter-defense against the bacterial restriction-modification system. (see https://doi.org/10.7554/eLife.61818). There are no SAM-degrading enzymes in other phages in seaphages.org. Thoughts on including this?
| posted today, 08:51
mthomas
There are several putative SAM-degrading enzymes in HollowPurple (e.g., SAM lyase –gp#120 w/ stop codon at 62,755 – evidence is based on HHpred hits; see the entry in PECAAN). If real, these are probably a counter-defense against the bacterial restriction-modification system. (see https://doi.org/10.7554/eLife.61818). There are no SAM-degrading enzymes in other phages in seaphages.org. Thoughts on including this?

Can you post the HHPRED coverage and percent identity? What do you get when you do an amino acid sequence alignment against the SAM lyase from T3?
 
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