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This abstract was last modified on June 5, 2019 at 9:59 a.m..
In the past decade, the SEA-PHAGES program has isolated and characterized thousands of phages, providing a wealth of genetic data to the broader scientific community. These data have already furthered our understanding of the diversity and evolutionary history of phage populations; they have also revealed the vast unknown contained within phage genomes. We believe that characterizing the functions of these phage genes is an important endeavor that will provide greater insight into phage-host and phage-phage dynamics and potentially inspire advances in therapeutics and molecular technologies. The SEA has expanded its Course-based Research Experience for undergraduates, adding SEA-GENES as a third semester course to build upon the exciting data generated by SEA-PHAGES. SEA-GENES research aims to experimentally explore the landscape of mycobacteriophage gene function. SEA researchers collaborate to develop molecular research tools and perform systematic phenotypic screens and other genetic analyses, collecting genome-wide and population-wide functional data and generating new hypotheses for future study. Here, we present an overview of the research strategy employed in the GENES course and highlight some of the exciting discoveries made by SEA-GENES researchers.