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This abstract was last modified on May 5, 2017 at 6:47 p.m..
Comparative genomic analysis of mycobacteriophage Iota and Gordonia and Rhodococcus phages shows nucleotide similarity among phages infecting these diverse hosts. Using several bioinformatics tools, including Phamerator, MUSCLE alignment software, and Dot Plot analysis, we found homology in the tail tube, baseplate assembly, and DNA polymerase genes between C1 cluster mycobacteriophage Iota and two Rhodococcus phages, Finch and E3, one Gordonia phage: Pupper, and one AA cluster mycobacteriophage Phrappucinio. All five of these phages are myoviridae. During the initial steps of phage infection, the recognition of a specific bacterial host is accomplished through the docking of phage’s tail fiber and base plate proteins with host cell surface receptors, and the similarity between these proteins in Iota and the Gordonia and Rhodococcus phages suggests that Iota may be able to also infect Gordonia and Rhodococcus bacteria. A broader host range in phages can impact their effectiveness in targeting specific bacteria for phage therapy and for biosensor assays.